Endocrine Abstracts

Introduction: The capability of exercise to induce useful effect on cardiovascular health could be partly attributed to its concomitant effect on adipokines and HDL cholesterol. Little information is available on whether post exercise concentration of these adipokines could be influenced by HDL cholesterol. Thus this study was designed to examine the possible independent effect of HDL cholesterol on serum level of adiponectin and retinol binding protein 4 following one session resistance exercise in healthy young men.

Method: Thirty-four healthy young BMI- matched male students (age, 20–26 years) were recruited. The study participants were allocated to experimental (n=18) and control (n=16) groups by using black balanced randomization method. The experimental group underwent a 120 minutes intensive resistance exercise session. Blood samples were taken at baseline and after 4 hours of training program to measure RBP4, adiponectin, HDL cholesterol and other cardio metabolic markers.

Results: The serum level of adiponectin, RBP4 and HDL cholesterol was not significantly different between two groups at baseline. We found that, after exercise concentration of adiponectin were negatively correlated with basal RBP4 and TG and positively correlated with basic level of adiponectin and HDL cholesterol.

Post exercise concentrations of RBP4 were negatively correlated with adiponectin and positively correlated with basal RBP4, age and BMI. Subsequent adjusted regression model showed HDL cholesterol (β=0.28, P=0.03) were the strong predictor of post exercise adiponectin concentration, explaining 28% of its variability. Whereas the basic level of RBP4 appeared to be the only predictor of after exercise RBP4 concentration (β=0.46, P=0.02) and HDL cholesterol has no role in this regard.

Conclusion: This study showed, HDL cholesterol, which was responsible for noticeable proportion of post exercise adiponectin variation, appeared to be a strong predictor of adiponectin but not for RBP4 following one session intensive resistance exercise in healthy young men.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.