Endocrine Abstracts

Introduction: Hypogonadism is associated with metabolic syndrome and all its individual components. This study analysed effects of normalization of serum testosterone in mainly elderly, hypogonadal men.

Methods: Prospective registry study of 252 men (mean age 60.6±8.0 years), with testosterone levels between ≤3.5 ng/ml. They received parenteral testosterone undecanoate 1000 mg at day 1, week 6 and every 12 weeks thereafter for up to 66 months.

Results: After 60 months the following changes were observed: systolic blood pressure declined from 153.74±17.61 to 137.74±10.92 mm Hg, diastolic blood pressure from 93.67±11.26 to 79.61±7.35 mm Hg. The changes were statistically significant vs baseline (P<0.0001). Both systolic and diastolic blood pressure reached a plateau within the second year of treatment.

Fasting glucose declined from 103.46±14.51 to 97.54±2.34 mg/dl. This decline was statistically significant vs baseline (P<0.0001), and a plateau was reached after ~2 years. HbA1c was only measured in a subset of 123 patients at baseline and declined from 6.97±1.55 to 6.01±1.41% after 60 months which was statistically significant vs baseline (P<0.0001).

C-reactive protein (CRP) decreased from 6.3±8.01 to 1.03±1.87 mg/dl (P<0.0001 vs baseline).

Conclusions: Raising serum testosterone to normal for up to 66 months resulted in improvements in blood pressure, glycemic control, and CRP.

Declaration of interest: I fully declare a conflict of interest. Details below:

Funding: This work was supported, however funding details unavailable.