ICEECE2012 Poster Presentations Cardiovascular Endocrinology and Lipid Metabolism (74 abstracts)
Variants of endothelial nitric oxide synthase gene are associated with components of metabolic syndrome in an Arab population
K. Alkharfy 1 , N. Al-Daghri 1 , O. Al-Attas 1 , M. Alokail 1 , A. Mohammed 1 , B. Vinodson 1 , M. Clerici 2 , U. Kazmi 1 , T. Hussain 1 & H. Draz 1,
1King Saud University, Riyadh, Saudi Arabia; 2University of Milano, Milano, Italy; 3National Research Centre, Cairo, Egypt.
Genetics plays a crucial role in the development of metabolic syndrome (MetS). Here we examined the association between endothelial nitric oxide synthase (eNOS) gene polymorphisms and MetS in a Saudi Arabian cohort to extend the understanding of the genetic basis of MetS in diverse ethnic populations. Anthropometric, clinical and biochemical parameters as well as genotyping for 894G>T, −786T>C variants of eNOS gene by PCR–RFLP and 4a/b by direct PCR were performed in 886 Saudi Arabians (477 MetS and 409 Non-MetS). The genotype distribution (TT, P=0.001; TC, P=0.001; TC+CC, P=0.001) and allele (T, P=0.007; C, P=0.007) frequency of the −786T>C SNP were significantly different between Non-MetS and MetS subjects which remained significant after Bonferroni correction. Moreover: i) the GT and GT+TT genotypes of the 894G>T SNP were associated with elevated blood pressure (P=0.017, and P=0.022 respectively); ii) the ab variant of 4a/b polymorphism was associated with decreased HDL levels (P=0.044); and iii) the TC+CC genotype and C allele of the −786T>C SNP were associated with increased fasting glucose levels (P=0.039, and P=0.028 respectively). Also, G-a-C was identified as the risk haplotype for MetS susceptibility (P=0.034). The result suggest a significant association of 894G>T, 4a/b and −786T>C polymorphisms with MetS and its components is present in an Arab population. A genetic predisposition to develop abnormal metabolic phenotypes, consistent with an increased prevalence of metabolic phenotypes can be detected in this ethnic group.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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