ICEECE2012 Poster Presentations Cardiovascular Endocrinology and Lipid Metabolism (74 abstracts)
The combined use of serum interleukin 6 and C-reactive protein is better than either alone in predicting cardiovascular events in a Chinese population
K. Lam 1 , W. Chow 1 , C. Yeung 1 , A. Tso 1 , M. Yuen 1 , C. Fong 1 , N. Wat 1 , T. Lam 1 , S. Lo 2 , H. Tse 1 & B. Cheung 1
1University of Hong Kong, Hong Kong, China; 2Hong Kong Hospital Authority, Hong Kong, China.
Objectives: Obesity is associated with an increase in cardiovascular risk. We investigated whether the measurement of obesity-related biomarkers could enhance the prediction of cardiovascular (CVD) events when used in conjunction with traditional risk factors.
Methods: We studied subjects in the Hong Kong Cardiovascular Risk Factors Prevalence Study 2 (CRISPS 2) cohort without previous cardiovascular disease. Baseline serum levels of several biomarkers known to be increased in obesity, C-reactive protein (CRP), interleukin 6 (IL6), and soluble tumor necrosis factor-alpha receptor-2 (sTNFR2; a surrogate marker of TNFα), as well as those of adiponectin, an adipokine with reduced expression in obesity, were measured.
Results: Of the 1848 subjects with no known CVD at baseline, 104 (5.6%) developed CVD events during a median follow-up of 6 years. The CVD group had higher baseline levels of CRP, IL6, and sTNFR2 (all P<0.001), but similar adiponectin levels (P=0.435), compared to the non-CVD group. Likelihood ratio test showed that elevated levels of CRP and IL6 (P<0.001, adjusted for traditional CV risk factors) but not sTNFR2 (adjusted P=0.05) were independent predictors of incident CVD. IL6 remained a significant predictor after adjustment for CRP levels. These two biomarkers, alone or in combination, significantly improved the prediction by traditional risk factors, as estimated by c-statistics (Delong P value being 0.0077, 0.035 and 0.0006 for CRP, IL6 and CRP+IL6 respectively). IL6 significantly increased the c-statistics when added to the model already including the traditional risk factors and CRP (Delong P=0.0393).
Conclusion: In this prospective study, CRP and IL6 were independent predictors of incident CVD in Hong Kong Chinese without prior CVD. The combined use of serum IL6 and CRP was superior to either alone in predicting CVD events in this community-based cohort.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
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