Endocrine Abstracts

Objective: The goal of this study is to evaluate the relationship between levels of adiponectin and vaspin, adiponectin/vaspin (A/V) ratio and metabolic syndrome, degree of adiposity, and insulin resistance (IR), as well as their correlation with metabolic variables.

Methods: Two hundred sixty patients with newly diagnosed type 2 diabetes (126 male, 134 female) were enrolled. Patients were grouped based on degree of adiposity, IR assessment (homeostasis model assessment of insulin resistance (HOMA-IR), and score of the International Diabetes Federation criteria for metabolic syndrome. Spearman’s correlation coefficients and multiple regression analysis were used to determine the association between serum vaspin or adiponectin levels and other continuous variables of interest, and logistic regression analysis to ascertain the association between serum levels of vaspin and adiponectin, with metabolic syndrome as dependent variable.

Results: Metabolic syndrome positive patients had more atherogenic lipid profile, were more insulin resistant, and had higher vaspin compared to metabolic syndrome negative patients. Patient displayed stepwise decrease in adiponectin level and A/V ratio showed, with increasing scores of the criteria for diagnosis of the metabolic syndrome, while an opposite trend was observed for vaspin levels. Using multiple logistic regression, the odds ratio of the metabolic syndrome as protect factor by vaspin was calculated to be 0.469 (95% CI, 0.252–0.873; P=0.017). Overweight/obese patients had significantly lower adiponectin levels, lower A/V ratio, and higher vaspin level compared to patients with normal body weight. Insulin-sensitive patients had significantly higher adiponectin levels, higher A/V ratio, and lower vaspin levels than those with IR, after BMI, WC and other variable were adjusted. Receiver operating characteristic analysis demonstrated that vaspin and A/V ratio had significantly higher area under the curve (AUC) for the detection of the metabolic syndrome.

Conclusion: For type 2 diabetes patients, serum levels of adiponectin and vaspin, as well as A/V ratio were associated with obesity, IR, and the expression of the metabolic syndrome. Vaspin and A/V ratio may be a more useful and relevant biomarker for molecular diagnosis of metabolic syndrome.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This work was supported, however funding details unavailable.