Endocrine Abstracts

Introduction: Components of metabolic syndrome, particularly overweight, dyslipidemia and diabetes mellitus (DM), are well known cardiovascular risk factors. The objective of this work was to evaluate the metabolic and glycaemic profile in patients (pts) with acute coronary syndrome (ACS), treated in our institution.

Methods: A total of 126 pts with ACS (unstable angina, acute myocardial infarction with /STEMI/or without ST-segment elevation/NSTEMI/) were admitted to the Coronary unit (CU) of a Department of Internal medicine, from January to December 2010.

We evaluated the following characteristics: sex, age, waist circumference, total cholesterol serum level, triglyceride level, HDL cholesterol level, LDL cholesterol level, plasma glucose concentration, uric acid, systolic (SBP) and diastolic blood pressure (DBP). All data were recorded at admission to CU. In patients with no previously known DM, and fasting plasma glucose concentration (FPG) ≥5.6 mmol/l measured the day after admission, the Oral glucose tolerance test (OGTT) was performed 1–3 days before hospital discharge.

Results: Of 126 patients studied, 73 pts (58%) were male. Five pts (4%) were hospitalized due to unstable angina, 56 pts (44.4%) had STEMI, and 65 pts (51.6%) had NSTEMI. Average age of pts was 64.9±13.65 years (min 33, max 89 years). Waist circumference was 101±3.2 cm in males, and 89.2±1.8 cm in females. Total cholesterol serum level was 4.93±1.28 mmol/l, triglyceride 1.95±0.89 mmol/l, HDL cholesterol 1.13±0.25 mmol/l, LDL cholesterol 2.90±1.08 mmol/l, plasma glucose concentration 7.65±3.78 mmol/l (min 4.4 mmol/l, max 26.9 mmol/l) and uric acid 350.9±114.2 mmol/l. Previously known DM was recorded in 40 pts (32%). According to OGTT test, 8 pts had impaired glucose tolerance (IGT), and 14 pts had newly diagnosed DM type 2.

Conclusion: High percentage of pts with occult or presenting DM, along with other metabolic abnormalities in ACS, suggest the need of early diagnosis and appropriate treatment of this conditions.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.