Endocrine Abstracts

Introduction: Coagulation and fibrinolysis defects were reported in primary hyperparathyroid(PHPT) patients. However, there is not enough data regarding platelet functions in this group of patients. Platelet functions of hyperparathyroid patients were measured in very few studies and they have conflicting results. Our aim was to evaluate the platelet functions in primary and secondary hyperparathyroid(SHPT) patients and to compare it with the healthy subjects.

Material and methods: In our study 25 subjects with primary hyperparathyroidism and 25 subjects with secondary hyperparathyroidism and 25 healthy control subjects were included. Platelet functions of the subjects were evaluated by using platelet rich plasma and platelet aggregation tests with epinephrine, ADP, collagen and ristosetin. Also, serum P selectin levels that indicates platelet activation level were measured in all subjects.

Results: There was no significant difference between the groups with PHPT, SHPT and the control group regarding the platelet aggregation tests. Also,there was no significant correlation between parathormone levels and aggregation parameters and between P selectin levels. When we separated the group of subjects with high serum calcium levels, there was also no significant correlation between aggregation parameters and serum calcium levels. We could not find any significant correlation between p selectin levels and serum calcium levels in this group of patients.

Conclusion: There is no significant effect of primary and secondary hyperparathyroidism and serum calcium levels on platelet functions evaluated with aggregation tests.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.