Endocrine Abstracts

Introduction: Vitamin D is important for bone and muscle development, function, and preservation. The serum 25OHD concentration is the best available clinical indicator of vitamin D status. The optimal serum 25OHD concentration is considered to be that level associated with maximal parathyroid hormone (PTH) suppression.

The aim: To determine the frequency of vitamin D deficiency and insufficiency in patients of different region of Ukraine and to evaluate the influence of 25OHDto bone mineral density (BMD).

Methods: It was examined 1575 people aged 20–80 yrs. old who lived in different regions of Ukraine. 25OHD and PTH level were evaluated by electrochemiluminescence method (Elecsys 2010, Roche). Vitamin D deficiency was diagnosed in level of 25-OH vitamin D below 49.5 nmol/l, vitamin D insufficiency – between 74.5 and 50.0 nmol/l. BMD was determined by ultrasound densitometry Sahara (Hologic) and DXA (Lunar).

Results: Vitamin D deficiency was registered in 81.8% persons, 13.6% examined had vitamin D insufficiency. It was determined negative significant correlation between PTH and 25OHD (r=−0.16, P<0.0000001). Secondary hyperparathyroidism was diagnosed in 11.9% patients. The mean level of 25OHD was significantly higher in southern resident of the country (P<0.001) and during summer (P<0.05). No significant correlation between 25OHD and BMD was found. But, only patients with vitamin D deficiency had significant negative correlations between PTH level and BMD at the level of femur neck (r=−0.12, P<0.004), dual femur (r=−0.09, P<0.004), upper and lower extremities (r=−0.11, P<0.01 and r=−0.10, P<0.01 accordingly), forearm 33% (r=−0.20, P<0.001).

Summary: In Ukrainian population the frequency of vitamin D deficiency is 81.8%. Only patients with vitamin D deficiency have significant negative correlations between PTH level and BMD at the level of femur neck, dual femur, forearm 33%, upper and lower extremities.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.