ICEECE2012 Poster Presentations Calcium & Vitamin D metabolism (73 abstracts)
Markers of bone turnover and polymorphism of vitamin D receptor gene in aging population: POLSENIOR study
D. Jedrzejuk 1 , A. Milewicz 1 , L. Laczmanski 1 , M. Puzianowska-Kuznicka 2, , M. Pawlak 1 , K. Kolackov 1 , A. Arkowska 1 , U. Mieszczanowicz 1 , B. Krzyzanowska-Swiniarska 5 & E. Bar-Andziak 4
1Wroclaw Medical University, Wroclaw, Poland; 2Mossakowski Medical Research Centre, Warszawa, Poland; 3Medical Research Center, Warszawa, Poland; 4Medical University of Warsaw, Warszawa, Poland; 5Pomeranian Medical University, Szczecin, Poland.
The levels of bone turnover markers are elevated e.g. in osteoporosis, neoplastic diseases with bone involvement (e.g. myeloma). Recently bone markers have been found to play an important role in other diseases, like cardiovascular diseases (CVD). Vitamin D, which plays a role in body metabolism, is also an important hormone maintaining bone homeostasis.
The aim of the study was to evaluate the levels of bone turnover markers (osteoprotegerin and ICTP) in vitamin D receptor gene polymorphisms in the population of responders of the POLSENIOR project.
Out of a group of 5695 randomly selected responders of the POLSENIOR study, blood was collected from 4737 individuals. Out of this group, 982 individuals (including 456 females and 526 males) aged above 65 had the levels of 25-OH-D3, ICTP and OPG (RIA method) measured. In order to amplify the genetic material, PCR was used. To identify polymorphisms of the VDR (Fok and Bsm) RFLP technique was used. The reaction products were analyzed by electrophoresis on 2% agarose gel.
No differences in the vitamin D level were found among the investigated polymorphisms in the whole investigated group. Among bone turnover markers, only in case of ICTP subjects with the bm polymorphic form (digested by BSM 1 enzyme) were characterized by lower ICTP level (on the borderline of significance=0.08). When the group was divided into genders, it appeared that in males the bm polymorphic form revealed also lower level of OPG, which reached the level of statistical significance (P=0.027).
Conclusions: Our studies demonstrated that the bm polymorphic form of vitamin D receptor may play a protective role against bone resorption.
Implemented under publicly-funded project no. PBZ-MEIN-9/2/2006.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
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Endocrine Abstracts
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