ICEECE2012 Poster Presentations Calcium & Vitamin D metabolism (73 abstracts)
Obesity, carbohydrate, lipid metabolism and polymorphisms (Fok, Bsm) of vitamin D receptor gene in aging population: POLSENIOR study
A. Milewicz 1 , L. Laczmanski 1 , M. Puzianowska-Kuznicka 5, , D. Jedrzejuk 1 , M. Pawlak 1 , K. Kolackov 1 , J. Chudek 2 , A. Arkowska 1 , U. Mieszczanowicz 1 , B. Krzyzanowska-Swiniarska 3 & E. Bar-Andziak 4
1Wroclaw Medical University, Wroclaw, Poland; 2Medical University of Silesia, Katowice, Poland; 3Pomeranian Medical University, Szczecin, Poland; 4Medical University of Warsaw, Warszawa, Poland; 5Mossakowski Medical Research Centre Polish Academy of Sciences, Warszawa, Poland; 6Medical Research Center, Warszawa, Poland.
Pleiotropic effects of vit. D in the etiology of obesity, metabolic syndrome and diabetes are still debated. So far published reports considered only changes in vit D plasma level in individuals with obesity and diabetes, and did not take into account the role of polymorphisms in the vit. D receptor gene.
The aim of the study was to evaluate obesity, carbohydrate and lipid metabolism and vitamin D level in two VDR polymorphisms (Fok and Bsm) in Polish aging population – POLSENIOR Study.
The study involved randomly selected out of 4737 individuals 982 subjects (456 women and 526 men) aged above 65, in whom the following measurements were performed: BMI, waist circumference, and blood serum HDL cholesterol, triglycerides, vitamin D, glucose and insulin (HOMA index) levels. In order to apply the genetic material, PCR was used. To identify polymorphisms, RFLP technique was used. The reaction products were analyzed by electrophoresis on 2% agarose gel. Statistical significance of the relationships between investigated metabolic parameters in relation to investigated polymorphisms was evaluated by means of the ANOVA test.
Results: Our findings revealed only statistically significant elevated levels of glucose for the polymorphic form digested with the Bsm enzyme of the VDR gene, both in homozygotes as well as heterozygotes, however when gender was taken into account, the statistical significance disappeared. The remaining metabolic parameters did not reveal and relationship to the investigated polymorphisms.
Conclusion: The polymorphisms VDR (Fok, Bsm) don’t plays key role in metabolic disorders in aging polish population implemented under publicly-funded project no. PBZ-MEIN-9/2/2006.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
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Endocrine Abstracts
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