Endocrine Abstracts

Introduction: Primary hyperparathyroidism is associated with cardiovascular disease. In addition, data about cardiovascular abnormalities in patients with asymptomatic primary hyperparathyroidsm (APHPT) is’nt clear. In this study, we aimed to examine the cardiac structure–functions and hs-CRP levels in patients with APHPT.

Materials and method: Thirty-one patients with APHPT and 32 sex- and age-matched control cases with similar cardiac risk factors were included.

Cardiac structure and functions were evaluated by two-dimensional Doppler echocardiography (PWD) and tissue Doppler echocardiography (TDI).

Results: Serum parathormone (PTH) and calcium (Ca) levels were higher in the APHPT group compared to the controls (181.38 (79–736) vs 58.36 (26.20–60.00) pg/ml P<0.001; 10.95±0.62 vs 9.46±0.30 mg/dl P<0.001). Left ventricular mass index (LVMI) was found to be significantly higher in APHPT group compared to the controls (112.09±25.74 vs 93.42±26.52 g/m², P=0.006). This statistical significance remained unchanged after the adjustment has been made according to the cardiovascular risk factors. LVMI was found to be correlated with the serum Ca level (r=0.260, P=0.038). Myocardial performance index (MPI) was significantly higher in the patient group compared to the controls (0.49±0.64 vs 0.39±0.48, P<0.001). MPI was found to be correlated to serum Ca (r=0.493, P<0.001), PTH (r=0.494, P<0.001), and LVMI (r=0.334, P=0.007). No difference was determined between two groups in terms of serum hs-CRP levels (2.38 (0.01–9.41) vs 3.07 (0.05–9.41) mg/l P=0.063). Also, no correlation was found between hs-CRP levels and LVMI and MPI (P>0.005).

Conclusion: Cardiac structure and functions are affected in patients with APHPT. These changes seem to occur independent of traditional cardiac risk factors, and correlated with serum PTH and Ca levels. Prognostic and clinical significance of these results should be investigated in larger and prospective studies.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.