Malignancy rate of thyroid nodules which defined as atypia of undetermined significance in the thyroid cytopathology

N. Cuhaci; D. Arpaci; S. Akbaba; G. Kiyak; S. Yalcin; G. Guler; R. Ersoy; B. Cakir

P1841

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Endocrine Abstracts (2012) 29 P1841

ICEECE2012 Poster Presentations Thyroid cancer (108 abstracts)

Malignancy rate of thyroid nodules which defined as atypia of undetermined significance in the thyroid cytopathology

N. Cuhaci ¹ , D. Arpaci ¹ , S. Akbaba ¹ , G. Kiyak ¹ , S. Yalcin ² , G. Guler ² , R. Ersoy ² & B. Cakir ²

Err

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Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey.

Aim: In this study, our aim is to evaluate the ultrasonographic features and histopathologic results of the thyroid nodules which are defined as AUS and contribute to the therapeutic approach of these nodules.

Methods: We evaluated 95 nodules of 92 patients, who have nodular or multinodular goiter and had diagnosed AUS at least in one nodule with fine-needle aspiration (FNA). Patients’ thyroid function tests, ultrasonographic features of the nodules and histopathologic results were evaluated.

Results: ###81.1% of patients were female, 18.9% were male. Mean age was 47.5±12.1 years. In the ultrasonographic features presence of microcalcification, border irregularity, peripheral vascularization and absence of hypoechoic halo was respectively 28.4%, 47.4%, 20% and 60%. 43.2% nodules were hypoechoic and 47.4% were solid. According to the histopathology, 63.2% of nodules (n=60) were benign, 36.8% (n=35) were malign. In malign nodules papiller carcinoma, well-differentiated thyroid neoplasm, follicular carcinoma and Hurthle cell carcinoma were found respectively 88.6%, 5.7%, 2.9%, and 2.9%. In malign nodules mean tumor size was 1.2±1.1 cm. No lymph node metastasis was found.

Conclusion: In AUS, malignancy rate is reported 25% of operated patients, but it is thought 5–10% of the total. In our study we found this ratio 36.8%. Our high ratio may be due to few and heterogeneous literature data outcomes. So, this high malignancy ratio in AUS nodules, have to be considered in the decision of operation.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector