ICEECE2012 Poster Presentations Thyroid cancer (108 abstracts)
Prevalence of differentiated thyroid cancer is relevant in patiens with familial adenomatous polyposis: a case-control prospective study
C. Diazzi 1 , P. Benatti 2 , L. Zirilli 1 , V. Gnarini 1 , B. Madeo 1 , S. Romano 3 , G. Rossi 2 , C. Carani 1 , M. Ponz de Leon 2 , L. Roncucci 2 & V. Rochira 1
Unit of Diabetology, Modena, Italy.
Introduction: Familial adenomatous polyposis (FAP) is a dominantly inherited disease characterized by colorectal adenomas, extracolonic gastrointestinal manifestations and extraintestinal diseases. Among them, differentiated thyroid cancer (DTC) is considered very frequent with an approximately risk 160 times higher than in general population, and with a prevalence of the cribriform-morular variant. As this esteem comes from scattered data, we evaluated in a prospective controlled study the prevalence of DTC in patients with FAP.
Methods: We enrolled 54 outpatients with FAP and 196 healthy subjects involved in a program of screening of thyroid diseases. All subjects underwent hormonal assay for thyroid function, ultrasonography (US) of the thyroid, fine-needle aspiration biopsy (FNAB) of all detectable nodules. Subjects with cytology suspicious for malignancy were addressed to thyroidectomy for histological verification.
Results: From the 54 FAP patients 19 (35.1%) had thyroid nodules: 2 (3.7%; mean age 34.05±SD 13.77 yrs) had a confirmed diagnosis of papillary thyroid carcinoma. From the 196 subjects of the control group 97 (49.4%) had thyroid nodules and 2 had a diagnosis of DTC (1%; mean age 48.17±SD 0.12 yrs).
Conclusion: Thyroid nodules is a common disease in patients with FAP (35.1%), as it is in the general population and in the control group of this study (49.4%). The prevalence of DTC was higher in FAP than in the control group and speak in favor of screening patients with FAP for thyroid cancer. The mean age at the time of the diagnosis of thyroid cancer in patients with FAP was lower than in the general population. These data confirm a possible correlation between FAP and DTC, suggesting the importance of a careful follow-up of thyroid lesions in these patients, even at young age.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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