Endocrine Abstracts

Women’s bone metabolism is regulated by estrogens and interleukins. During the menopausal period the estrogens’ protective activity is decreased and the production of IL1β and IL6 is increased.

The aim of the study

The assessment of the dependency between IL1β i IL6 and estradiol values and BMD and IBM in postmenopausal women.

Material: Forty-eight women, age 49–61, without menstruation and not edocrinologically treated. Group I – 19 women with normal BMD, Group II – 29 women with osteoporosis.

Methods: Densitometric (BMD, T-score). Radioisotopic dynamic and static scintigraphy Tc 99 m MDP and IBM designation. Biochemical interleukins IL1β and IL6 and E2, P, ALP, Ca+i TSH.

Results: In Group I - IBM within the normal values range 86.2<IBM<98.9, in Group II, the IBM within 75.1<IBM<90.3 (in 40% of women the IBM was below the normal values).

Group I – a strong positive correlation between BMD and IBM

Group II – a medium positive correlation between BMD and IBM

Group I – normal biochemical and hormonal values

Group II – elevated concentrations of phosphatase and phosphates.

The estradiole value in Group I was higher than in Group II. The difference was statistically significant.

The interleukins concentrations in Group II were significantly higher than in Group I (statically significant P=0.000).

In Group I there was no correlation and in Group II a negative correlation between BMD and interleukins.

Conclusions: During the menopausal period the estradiol’s decrease is accompanied by the increase of interleukins IL1β and IL6 which results with the loss of bone mass and slower bone metabolism and degradation of bone quality parameters.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.