Endocrine Abstracts

Objective: Skeletal disability pathogenesis is multifactorial. Many studies have proved a negative relation of smoking on calcium-phosphate metabolisms, bone density and quality; however in some other papers these results have not been confirmed. The aim of the study was to monitor the influence of the length of smoking, a number of cigarettes smoked and the age of the first use of cigarettes on the whole-body bone density.

Methods: Whole-body densitometry determining bone and soft tissues using dual-emission X-ray absorptiometry (DXA) was measured with 40 women, where 22 women were premenopausal (average age 35±8) and 18 women postmenopausal (average age 57±5). All probands had been smoking in the long term continuously until the day of examination. Partial correlations adjusted to constant age and physical activity were used to evaluate relations between the smoking intensity indicators on one side and anthropometric characteristics and bone quality indicators on the other side.

Results: Monitoring the effect of smoking upon whole-body bone density and the volume of muscle mass with women, we have not proved statistically significant relation of the whole-body mass to the number of cigarettes smoked, or to the length of smoking, or to the age of the first use of cigarettes.

Conclusions: Though the study is not fully comparable with those monitoring the relation of smoking to bone density of the selected high-risk skeleton localities, fundamentally it comes up with the identical results when compared with other studies.

Acknowledgement: Supported by grant IGA MZCR NT 12340-5, and by project ‘Advanced education of own staff in clinical and molecular endocrinology’ (CZ.2.17/1.1.00/32386).

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This work was supported, however funding details unavailable.