Endocrine Abstracts

The aim of this study is evaluating body composition in postmenopausal women depending on presence of vertebral fractures in their anamnesis.

Materials and methods: We’ve examined 144 postmenopausal women aged 50–83 years (mean age – 62.9±0.7 years; mean height – 160.6±0.5 cm; mean weight – 71.9±1.2 kg). The patients were divided into two groups: group A – women without vertebral fractures (n=82), group B – women with vertebral fractures (n=62) in their anamnesis. We also divided the patients into the following age-dependent groups: 50–59 years, 60–69 years, 70 years and older. Total body, lumbar spine, femoral neck bone mineral density (BMD), lean and fat masses were measured by DXA using a densitometer Prodigy, GE.

Results: Fat mass significantly decreased with age (50–59 years – 31 906.9±1508.0 g; 60–69 years – 30 876±1186.5 g; 70 years and older – 25 257.4±1398.6 g; F=5.0; P=0.008). Lean mass didn’t show significant differences. Fat and lean masses in postmenopausal women with vertebral fractures were significantly lower compared with the data of women without vertebral fractures (fat mass: group A – 42 089±583.4 g, group B – 38 421.4±652.4 g, F=17.4, P=0.00005; lean mass: group A – 31 783.7±1212.1 g, group B – 27 831.4±1048.5 g, F=5.6, P=0.02). We have founded the positive significant correlation between fat mass and BMD of spine and femoral neck depending on the presence of vertebral fractures in patient’s anamnesis:

- Group A: total fat (g)=1.06+0.26×BMD (L1–L4); r=0.07; t=2.40; P=0.02.

Total fat (g)=0.87+0.34×BMD (femoral neck); r=0.12; t=3.23; P=0.002.

Group B: total fat (g)=0.84+0.45×BMD (L1–L4); r=0.20; t=3.91; P=0.0002.

Total fat (g)=0.70+0.32×BMD (femoral neck); r=0.10; t=2.54; P=0.01.

Conclusion: Fat mass was significantly decreased with age. Fat and lean masses significantly differ in postmenopausal women depending on the presence of vertebral fractures in their anamnesis. The positive significant correlation was found between fat mass and BMD of spine and femoral neck.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.