ICEECE2012 Poster Presentations Thyroid (non-cancer) (188 abstracts)
The role of surgery in the treatment of amiodarone-induced thyrotoxicosis (AIT)
L. Tomisti , G. Materazzi , A. Marchello , M. Moretti , L. De Napoli , S. Brogioni , P. Miccoli , F. Bogazzi & E. Martino
University of Pisa, Pisa, Italy.
Introduction: AIT develops in 15–20% of patients receiving amiodarone. Patients with persistent thyrotoxicosis or those with instable cardiac function, may be candidate for thyroidectomy; however, thyrotoxicosis and underlying cardiovascular disease may increased surgical risk.
Matherials and methods: We retrospectively selected 23 AIT patients treated with a total thyroidectomy, from January 2000 to December 2010 [19 men, 4 women; mean (+SD), age 61.4±9.4 years, range, 46–79 years]. Nineteen patients have been operated, during hyperthyroidism, after a short course of iopanoic acid (1 g/die for 15.2±7.7 days).
Results: No death occurred during surgery; in addition no excessive bleeding or intraoperative arrhythmic event occurred. One subject presented atrial fibrillation 24 hours after surgery, requiring a short course of sotalol, with reinstitution of sinus rhythm. One patient experienced hypoparathyroidism and one experienced laryngeal nerve injuries. No deceased after a 12-month follow-up. Impaired cardiac conditions, with ejection fraction (EF) < 35% (mean 27±6.7%), was observed in 8 patients before surgery. In these patients a significant EF improvement (mean 37.2±8.38%, P=0.05) was observed 60 days after surgery and reinstitution of euthyroidism
Conclusions: Total thyroidectomy is a valid option for treating AIT patients that require a rapid restoration of euthyroidism, which is associated with improvement of cardiac function.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector
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Endocrine Abstracts
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