Endocrine Abstracts

Introduction: Androgen stimulation of prostate cancer (PCa) cells has been the basis for extensive studies evaluating the role of androgen in PCa but the diagnostic measurement of androgen as well as androgen values that potentially influence prognosis are unclear in patients with PCa. The aim of this studies is to analyze the hormone behavior in the prostate cancer (PCa), as well as the relationship between PSA-testosterone and testosterone-aggressiveness tumor and compare these results with those obtained in patients with benign prostatic hypertrophy (BPH).

Methods/design: We performed an observational study of cases and controls, between January and October 2011. We selected 30 cases diagnosed with PC and 15 controls diagnosed with BPH. The concentrations of total testosterone, SHBG-testosterone, FSH, LH, Prolactin, Progesterone and Estradiol were measured in both groups. For statistical analysis we calculated the Pearson correlation test and Student t-test between variables in both groups, using the statistical package 17.0 SPPS.

Results: In the cases group it was found a negative correlation between PSA and testosterone levels (P=0.03), positive PSA with estradiol and progesterone (P<0.01), and positive relationship between LH and FSH (P <0.01). We did not found significant differences in hormone levels.

Conclusions: No significant differences were found between groups or between patients with PCa based on their aggressiveness, as well as significant correlations between the values within each group.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector