Adiponectin and cardiac structure in acromegaly

S. Gurbulak; F. Akin; E. Yerlikaya; S. Topsakal; H. Tanriverdi; B. Akdag; B. Kaptanoglu

Adiponectin, is an adipocyte derived hormone possess insulin-sensitizing, antiatherogenic, and antiinflammatory properties. The aim of this study to evaluate adiponectin levels at acromegalic patients according to healthy subjects in relation with ecocardiographic findings. We included 30 subjects (15 male, 15 female) were diagnosed as acromegaly and 30 healthy (10 male, 20 female) subjects. Mean ages of both group were similar. Serum glucose, insulin, GH, IGF1 (insulin like growth factor 1), adiponectin levels were obtained and insulin resistance were calculated by HOMA-IR. Echocardiography of subjects were performed. Adiponectin levels were significantly higher at acromegalic group than control group. At acromegalic group, there was no statistically meaningful relation between serum adiponectin and GH, IGF1 levels. IVST (thickness of interventricular septum in diastole), PWT (thickness of left ventricular posterior wall in diastole), LVMI (left ventricular mass index), E/A ratio, DT (deceleration time of E-wave), ET(ejection time), IVRT (Isovolumetric relaxation time), VPR (velocity of mitral flow propagation), LVESV (left ventricle end systolic volume) values were increased results were statistically meaningful. At acromegaly group adiponectin levels were positively related with LVMI. Adiponectin levels may be indicator of the cardiac involvement acromegaly.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This work was supported, however funding details unavailable.

Clinical and echocardiographic findings of groups.
	Acromegaly (n=30)	Control (n=30)	P value
BMI (kg/m²)	29.06±6.08	25.06±2.78	0.001*
FPG (mg/dl)	113.53±28.87	89.20±6.26	0.001*
Insulin (μIU/ml)	8.38±9.43	6.51±2.45	NS
GH (ng/l)	15.39±14.13	0.68±1.29	0.001*
IGF1 (ng/l)	649.53±373.45	124.54±44.86	0.001*
Adiponec tin (μg/ml)	84.13±101.18	28.84±58.72	0.001*
IVST (mm)	10.46±1.38	6.93±2.93	0.000*
PWT (mm)	10.36±1.67	6.93±3.03	0.000*
LVMI (g/m²)	122.98±30.18	76.65±15.08	0.000*
E/A ratio	0.98±0.31	1.19±0.36	0.044*
DT	219.83±50.99	191.06±32.9	0.012*
ET	314.03±40.04	276.93±26.72	0.000*
IVRT	106.20±15.34	97.00±11.73	0.012*
VPR	59.83±14.24	45.06±8.87	0.000*
LVESV	39.13±11.24	31.90±11.06	0.001*
EF (%)	63.00±6.55	64.06±5.63	NS
*P value<0.05; statistically significant. NS: Non significant. EF: Ejection fraction.

Endocrine Abstracts

P1535