Endocrine Abstracts

Objective: To evaluate frequencies of mood disorders in males and females with acromegaly and to compare their quality of life with that of control males and females of the same age.

Patients and methods: males (age 48.8±10.3 yers) and 16 females (age 52.9±13.7 years) with acromegaly after pituitary adenomas; 13 control males (age 46.3±18.6 years) and 43 control females (age 54.8±9.8 years).

Mood disorders diagnosed by Mini-International Neuropsychiatric Interview (MINI), quality of life evaluated by WHO Bref Quality of Life Questionnair.

Results: Current depression was diagnosed in 2 (18.2%) males and 1 (6.7%) female with acromegaly, depression episodes in the past - in 0 males and 1 (6.7%) females with acromegaly, social phobia - in 0 males and 2 (13.3%) females with acromegaly, general anxiety disorder - in 4 (36.4%) males and 3 (20.0%) females with acromegaly.

Comparing quality of life: Domins of physical health (13.9±2.5 vs 16.1±2.8) and social relations (14.5±2.0 vs 16.3±1.6) were significantly worse in acromegalic than in control males; environmental domain (15.2±1.2 vs 12.8±2.8) was significantly better in acromegalic than in control females.

In conclusion, Mood disorders were diagnosed in males and females with acromegaly after pituitary adenomas; quality of life (in domains of physical health and social relations) was found worse in acromegalic than in control males.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.