Endocrine Abstracts

Introduction: Hyperprolactinemia has been associated with dyslipidaemia, hypercoagulability, impaired endothelial function and decreased insulin sensitivity. Recent data show that prolactin hormone (PRL) could contribute to atherogenesis. The aim of our study was to investigate the relationship between MPV and PRL, androgen hormones, lipid profiles in premenopausal prolactinoma patients, who did not have insulin resistance (IR).

Methods: Thirty-nine newly diagnosed premenopausal prolactinoma patients (mean age 28,6±6,6 years, mean body mass index (BMI) 23,6±1,9 kg/m2, mean HOMA-IR 1,33±0,4.) and twenty normoprolactinemic, age- and BMI- matched healthy control females were involved in the study. Blood samples were taken for total blood count including MPV, FSH, LH, estradiole, total testosterone (TT), free testosterone (FT), androstenedione (A), dehydroepiandrosterone-sulfate (DHEAS), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), insulin and fasting glucose (FG). IR was calculated by HOMA-IR(fasting glucose (mg/dl) x serum insulin (μIU /ml) /405).

RESULTS: There was no difference between prolactinoma and control group regarding to age, BMI and and waist circumference (P>0.05, for all). PRL, FT and MPV in women with prolactinoma were significantly higher than the control group (P<0.01, P<0.01, P=0.013). No significant differences were observed in the groups according to HDL-C, LDL-C, triglyceride, HOMA-IR, gonadotropin and the other androgen hormone levels (P>0.05, for all). Both PRL and triglyceride levels showed a positive correlation with MPV levels (r=0.727, P<0.001, r=0.357, P=0.026, respectively) and a negative correlation between HDL-C and MPV levels was found in our study group (r=−0.437, P=0.005).

Conclusion: Our study demonstrated the positive correlation between MPV levels with both PRL and triglyceride levels. Also a negative correlation between HDL-C and MPV in prolactinoma patients. Hyperprolactinemia and hypertriglyceridemia might be cause platelet reactivity through elevating MPV levels in prolactinoma patients. Similarly, it could be said that, high HDL-C may be protect from atherosclerosis by lowering MPV in prolactinoma patients.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector