ICEECE2012 Poster Presentations Pituitary Clinical (183 abstracts)
Evaluation of cardiovascular risk factors and metabolic profile in hyperprolactinemic subjects
M. Sayki Arslan 1 , M. Sahin 2 , T. Esra 1 , E. Cakir Ozkaya 1 , N. Bozkurt Colak 1 , B. Karbek 1 , I. Ozturk Unsal 1 , B. Ucan 1 , A. Gungunes 1 , E. Cakal 1 , M. Ozbek 1 , O. Topaloglu 1 , T. Demirci 1 , M. Karakose 1 , M. Caliskan 1 , Z. Ginis 3 & T. Delibasi 1
1Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey; 2School of Medicine, Ankara University, Ankara, Turkey;3Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Objective: Hyperprolactinemia has been reported to be associated with abnormalities of glucose metabolism and cardiovascular inflammatory markers. However, the metabolic effects of high prolactin levels are not adequately clarified. The aims of this study were to evaluate the effects of hyperprolactinemia on endothelial function, insulin sensitivity and inflammatory markers in prolactinoma diagnosed subjects.
Methods: In total, 58 hyperprolactinemic subjects, 18 men and 40 women, aged 38.9±10.6 years with newly diagnosed pituitary adenomas were recruited from our outpatient clinic. In total, 30 healthy subjects, without any known disease, of similar age, gender and body mass index (BMI) were included to serve as control group. The study was approved by the Hospital Ethical Commitee and informed consent was obtained from all patients. All subjects underwent measurements of height, weight, waist and hip. BMI and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Metabolic variables were obtained after an overnight fasting. Metabolic syndrome (MS) was diagnosed using the Adult Treatment Panel III criteria. Endothelial function was determined by measuring carotid intima media thickness (CIMT) on high resolution external ultrasound.
Results: Serum levels of glucose, insulin, HOMA-IR, total cholesterol, triglyceride and waist circumference were significantly higher in the patient group in comparison with the controls. No significant difference were observed in blood pressure measurements. Although high sensitive C-reactive protein levels were similar between groups (P=0.094), CIMT measurements were significantly higher in hyperprolactinemia patients (P=0.002). The prevalance of obesity, overweight, MS, and IR was 43.1%, 29.2 and 27.6% respectively in patient group.
Conclusion: Based on the results of this study, hyperprolactinemia is associated with endothelial dysfunction and decreased insulin sensitivity, which are early markers of atherosclerosis. Metabolic control must be considered in the clinical management of patients diagnosed prolactinoma.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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