ICEECE2012 Poster Presentations Pituitary Clinical (183 abstracts)
Comprasion of cycline D1 gene (Ccnd1) polymorphism in invasive and non-invasive prolactinomas
S. Cander 1, , E. Erturk 1 , M. Karkucak 1 , O. Oz Gul 1 , T. Yakut 1 , O. Unal 1 , C. Ersoy 1 , E. Tuncel 1 & S. Imamoglu 1
1Uludag University Medicine School, Bursa, Turkey; 2Bursa Sevket Yilmaz Education and Research Hospital, Bursa, Turkey.
Cycline D1 gene that plays a crucial role in a cell cycle, have been shown to be expressed more in nonfunctioning pituitary adenomas and functioning invasive pituitary adenomas compared to normal hypophisis tissue and noninvasive pituitary adenomas. A/G polymorphism in CyD1 gene exon 4/intron 4 regions have been demonstrated to affect clinical outcomes and survey in some tumors. Objective of this study was to investigate the effect of polymorphism of cycline D1 gene on the tumor invasiveness in prolactinomas.
A hundred and thirteen patients followed-up in the Uludag University, Department of Endocrinology and Metabolic Diseases, with the diagnosis of prolactinoma were included in the study. The patients were divided into two groups as noninvasive and invasive tumors according to radiological findings. The cyclin D1 gene A870G polymorphism was determined in all patients with PCR.
Rates of GG, GA and AA genotypes were found as 11.8, 55.9 and 32.4%; respectively, in the noninvasive group, while these rates were defined as 15.6, 44.4 and 40.0%; respectively, in the invasive group. Although the rate of AA genotype was found higher in the invasive than in the noninvasive group, the difference was not statistically significant. The rate of A allele was found as 60.3 and 62.2%, while the rate of G allele was defined as 39.7 and 37.7% in the noninvasive and invasive groups; respectively. A/G ratio in the total alleles was found as 1.52 in the noninvasive group and 1.65 in the invasive group.
Although A allele incidence was slightly higher in the invasive adenomas compared to the noninvasive adenomas, this difference also was not statistically significant. It did not affect the features of the tumor defined in the imaging findings, reveals the result of this could not be demonstrated as a factor in prognosis of the disease.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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