ICEECE2012 Poster Presentations Bone & Osteoporosis (67 abstracts)
Evidence for vitamin D deficiency and increased fractures’ prevalence in autoimmune bullous skin diseases
C. Eller-Vainicher , A. Marzano , V. Trevisan , E. Cairoli , V. Zhukouskaya , L. Marchese , V. Morelli , P. Beck-Peccoz , C. Crosti & I. Chiodini
Fondazione Ca’Granda Ospedale Maggiore Policlinico IRCCS, Milan, Italy.
Background: Vitamin D deficiency plays a role in autoimmune diseases and risk of fractures. No data are available on vitamin D levels and vertebral fractures in autoimmune bullous skin diseases.
Objectives: To assess vitamin D serum levels and vertebral fractures’ prevalence in patients with pemphigus vulgaris (PV) and bullous pemphigoid (BP), potentially deadly autoimmune bullous disorders.
Methods: We studied 13 consecutive active untreated inpatients with PV (six males, seven females, age 53.5±14.3 years), 15 with BP (seven males, eight females, age 76.9±12.4 years) and 28 age- body mass index- and sex- matched controls. In all subjects, the 25(OH)Vitamin D (25OHD) levels and presence of vertebral fractures by spinal radiographs were assessed.
Results: In PV patients, 25OHD levels were lower (12±4.4 ng/ml) and prevalence of severe hypovitaminosis D higher (61.5%) than in controls (22.2±11.7 ng/ml, P=0.012; 23.1%, P=0.0047, respectively). The prevalences of fractures were 53.8 and 30.8% in PV patients and controls, respectively. Patients with BP showed lower 25OHD levels (9.6±7.2 ng/ml) and higher prevalence of severe hypovitaminosis D (73.3%) than controls (22.6±18.7 ng/ml, P=0.022; 26.7%, P=0.01, respectively). The prevalences of fractures tended to be higher in BP patients than in controls (66.7 vs 33.3%, respectively, P=0.068).
Conclusions: The low 25OHD levels found in PV and BP may suggest a role for this agent in their pathogenesis. The increased prevalence of fractures should be taken into consideration in patients who must be given corticosteroid.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
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