ICEECE2012 Poster Presentations Pituitary Basic (30 abstracts)
Evidence of the involvement of gherline and obestatin in the regulation of GH secretion during pubertal development in boys
N. Kausar 1 , A. Naseem 1 , S. Bibi 1 , S. Aslam 2 , M. Irfan 1 , M. Qayyum 1 , R. Yousaf 1 , R. Mansoor 3 , S. Murtaza 4 & S. Rizvi 5,
1PMAS Arid Agriculture University, Rawalpindi, Pakistan; 2Government College University, Lahore, Pakistan; 3Rawalpindi Medical College, Rawalpindi, Pakistan; 4Nuclear Oncology and Radiotherapy Institute, Islamabad, Pakistan; 5Pakistan Science Foundation, Islamabad, Pakistan.
The oxyntic mucosa of digestive tract secretes two peptide hormones, ghrelin and obestatin, which are derived from the same gene transcript and play an important role in food intake, metabolic responses and growth and reproduction. Ghrelin and obestatin bind GH secretagogue receptor GHSR1α and G-protein coupled receptor GPR39 respectively, in the pituitary. A limited data in the literature demonstrate that levels of ghrelin peak during first 2 years of life and thereafter decline until the end of puberty, whereas the sensitivity of GHSR increases during puberty since hexareline, a synthetic GHSR analogue, induces greater GH responses in pubertal boys compared to prepubertal boys. Though a role of obestatin in augmentation of GH secretion in vitro has recently been observed, the involvement of obestatin in GH secretion in vivo especially at puberty is 1. A possible association of ghrelin and obestatin with increase in GH secretion during puberty was aimed at. Blood samples were collected from 10 to 20 years old 407 boys and plasma concentrations of T, GH, ghrelin and obestatin were determined using specific ELISA. Data were analyzed using Student’s t test, ANOVA and Pearson correlation. The concentrations of T remarkably increased during mid puberty. Ghrelin showed 1st peak at 14 year, followed by a peak of GH at 15 years and a 2nd peak of ghrelin at 17 years. Obestatin exhibited an abrupt increase at early puberty, gradually augmented during mid puberty and peaked at 17 years. T, ghrelin and obestatin were positively correlated with GH secretion at early and mid puberty. GH, T, ghrelin and obestatin were positively correlated with linear growth velocity at early and mid puberty. The present study demonstrates that the secretion of ghrelin and obestatin increases during puberty and may play a role in increase in GH secretion at puberty.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
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