ICEECE2012 Poster Presentations Paediatric endocrinology (47 abstracts)
The presence of thyroid nodules in our morbid obese patients and its relation with metabolic parameters
M. Sahin , H. Temizhan , B. Ucan , E. Cakal , M. Ozbek , H. Karakose Dogan , I. Ozturk Unsal , A. Gungunes , N. Colak Bozkurt , M. Sayki Arslan , E. Cakir Ozkaya , B. Karbek , H. Yilmaz , E. Tutal Akkaya & T. Delibasi
Diskapi Training and Research Hospital, Ankara, Turkey.
Objective: Insulin resistance may contribute to the development of nodular thyroid disease. Changes in thyroid morphology have been reported in obese patients. In this study, we examined the frequency of nodular thyroid disease in morbid obese patients (BMI>40 kg/m2) and investigated the metabolic parameters which may play a role in thyroid nodule formation.
Methods: Three hundred and six morbid obese patients (296 women, 10 men) (age 46.2±11) without known thyroid disease were included in the study. Thyroid ultrasonography was performed, HOMA-IR, HOMA-% B and HOMA-% S was measured in all patients.
Results: Age, waist circumference, HOMA-% B, vitamin-D3, LDL-cholesterol, TSH was significantly correlated with thyroid volume after regression analysis (P<0.05) (adjusted R2 value is 0987). A 153 (50%) patients had nodules which was greater then normal population. Presence of nodules were significantly correlated with the age, weight, waist circumference, and HDL-cholesterol level of free T4 after logistic regression analysis (P<0.05). Nodule volume was significantly associated with age, HOMA-% B, HOMA-IR, vitamin B12, and fasting glucose after regression analysis (P<0.05) (adjusted R2 value 0689). There were no significant differences in the incidence of nodules according to presence of insulin resistance or presence of diabetes in these patients. There was no correlation with metabolic syndrome criteria and nodule presence.
Conclusion: Unlike low frequency of thyroid nodule in obese people in recent studies, we found higher frequency of thyroid nodule in our morbid obese patients. In obese patients, metabolic parameters may play an important role in thyroid volume, nodule formation and nodule volume.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
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