ICEECE2012 Poster Presentations Bone & Osteoporosis (67 abstracts)
Vitamin D and estrogen receptors’ polymorphisms in postmenopausal women
S. Oros 1 , O. Ianas 1 , S. Vladoiu 1 , M. Giurcaneanu 1 , E. Neacsu 1 , G. Voicu 1 , M. Stoiceanu 1 , R. Rosca 1, , C. Neamtu 1 , C. Badiu 1, & C. Dumitrache 1,
1C.I. Parhon National Institute of Endocrinology, Bucharest, Romania; 2Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Osteoporosis is a polygenic disease. The intensive search for genetic markers has led to the identification of several genetic polymorphisms, associated with the decrease of bone tissue and therefore a higher risk of osteoporosis.
The study aimed to evaluate estrogen receptor alpha (ESR1) and vitamin D receptor (VDR) polymorphisms in postmenopausal women with or without osteoporosis and their correlations with bone markers and adipocytokines.
Subjects and methods: We enrolled 56 postmenopausal women, aged over 60, without treated osteoporosis and no secondary osteoporosis. Subjects were divided into two groups: group 1 – postmenopausal women with osteoporosis (19 subjects), group 2 – postmenopausal women without osteoporosis (37 controls).
Hematological, biochemical profile, bone turnover markers and adipocytokines were assayed. DXA of the spine and the left hip was performed. ESR1 (XbaI and PvuII) and VDR (Bsm I, ApaI, TaqI and FokI) polymorphisms were determined by RFLP method on genomic DNA.
Results were statistically analyzed using SPSS program.
Results: Genotype distribution differed significantly in the osteoporosis group compared to controls for ESR1 PvuII (P=0.03) and XbaI (P=0.04) polymorphisms. VDR polymorphisms genotype distribution did not significantly differ between the two groups.
We found higher TNFα mean values in bb genotype (4.506±0.92) compared to Bb genotype (1.472±0.53, P=0.036) and TT with Tt genotype (P=0.03) in group 1.
Higher CRP mean values were present for PP genotype compared to Pp (P=0.046) in controls. In controls, VDR BsmI, Bb genotype associated lower T hip scores (P=0.035) and lower BMD compared to BB genotype and lower T hip scores (P=0.035) where present associated with VDR Taq1, Tt genotype compared to tt genotype.
Conclusion: XbaI and PvuII estrogen receptor α polymorphisms may be involved in the pathogenesis of osteoporosis, while Bsm I and TaqI VDR polymorphisms may influence BMD, bone turnover and the inflammatory state.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
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Endocrine Abstracts
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