Endocrine Abstracts

Obesity is a major risk factor for chronic non communicable diseases and plays a central role in the insulin resistance or metabolic syndrome, which includes hyperinsulinemia, hypertension, hyperlipidemia, type 2 diabetes mellitus, and an increased risk of adult onset obesity and atherosclerotic cardiovascular disease (1). Insulin resistance is a state in which a given concentration of insulin produces a less than expected biological effect. The metabolic syndrome is a clustering of cardiovascular risk factors that arises from insulin resistance accompanying abnormal adipose deposition and function.

Aim of the work: The aim of this study was to the insulin resistance in overweight and obese children as insulin resistance resistance could be used an early marker of type 2 diabetes.

Subjects and method: overweight and obese children aged from 6 to 18 years (mean=11.94+3.51 years), were selected from the outpatient pediatric endocrinology clinic in National Institute of Diabetes & Endocrinology. Another 20 lean children were selected as a control group.

Results: The results of this study showed that All subjects were investigated for body mass index (BMI), study of HOMA-IR, B.P. measurements, serum cholesterol and triglycerides for study group were 33.09+6.07, 2.96+1.46, 152.16+28.84 mg/dl respectively. There was a positive significant correlations between BMI and HOMA-IR, HOMA-IR and Cholesterol and between HOMA-IR and BMI.

Concussions: It could be concluded that we have to measure HOMA-IR in any overweight and obese for early detection of insulin resistance. It could be recommended to try to control overweight and obesity as obesity is the golden gate to insulin resistance and diabetes.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.