Endocrine Abstracts

Introduction: Morbid obesity is associated with systemic inflammation, possible impaired glucose toleration and changes in serum lipids. Association of these parameters is risk for atherosclerosis and cardiovascular diseases.

Methods: We have analyzed body weight, BMI, lipid profile, glucose, HbA1c and C reactive protein in 36 obese subjects, 8 males and 28 females, 37.9 (±18.6) years of age, before and three monts after bariatric surgery. There was performed laparoscopic restrictive-malapsorptive bariatric technique (Roux en Y gastric by pass). All of them were on 1200–1500 kcal balanced, medical nutritive therapy after surgery. Before surgery mean body weight was 130.4±44 kg, BMI 43±17.1 kg/m², blood glucose 5.13±3.8 mmol/l, HbA1c 5.78%, total s-cholesterol 5.23 mmol/, HDL-C 1.15 mmol/l, LDL-C 3.04 mmol/l, triglycerids 2.11 mmol/l, CRP 13.3 mg/l.

Results: Three monts after bariatric surgery body weight loss was 23±9 kg, 17.6% (P<0.05), BMI decreased 5.9 kg/m², 18% (P<0.05), glucose lowering was 1.5±1.4 mmol/l (P<0.05), HbA1c was lower 0.58, 12.3% (P<0.05). Changes in serum lipids was: s-cholesterol decreased 1.97 mmol/l, 37.6% (P<0.01), LDL-C 0.91 mmol/l, 29.1% (P<0.05), triglycerids 0.97 mmol/l, 42% (P<0.01). There was no significant changes in HDL cholesterol level and after 90 days HDL-C was 0.11 mmol/l lower, 9% (P>0.05). Decreasing in C reactive protein was 11 mmol/l, and that was most significant change of 82% (P<0.001).

Conclusion: Weight reduction due to bariatric restrictive-malabsorptive procedures and following medical nutritive therapy, improves lipid parameters, glycated hemoglobin, lowering systemic inflammation and risk for atherosclerosis and cardiovascular diseases in morbid obesity subjects.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.