Endocrine Abstracts

Aim of research: To determine uric acid level in blood serum and incidents of hyperuricemia among women and men of different age and their relation with some components of metabolic syndrome.

Object of research: Women (n=450) and men (n=120), age of examined patients was from 20 to 89 years old. They were divided into the following groups: I group (BMI=18.5–24.9), II group (BMI=25.0–29.9), III group (BMI=30.0–34.9), IV group (BMI>35). Average age of examined patients was 60.4±0.7 years.

Methods of research: Uric acid level of blood plasma was determined by uricase-peroxidase method. Statistic analysis was performed by Statistica 6.0.

Results: The level of uric acid increased with age in women and had a significant difference in women of 80–89 years (r=0.18, P<0.05). In men the maximal level of uric acid was in the group 60–69 years. Incidence of hyperuricemia among women was 17%, in men −30%. We determined that the highest level of triglyceride, cholesterol, systolic and diastolic pressure was among women and men with hyperuricemia. The higher level of uric acid was found among women in postmenopausal period with maximal body mass index (BMI>35). In the I group level of uric acid was 277.52±8.40 μmol/l; in II group – 286.81±7.79 μmol/l; in III group – 291.81±7.56 μmol/l, in IV group – 327.17±12.17 μmol/l. Incidence of hyperuricemia among women in the I group was 10.2%, in II group – 15.9%; in III group – 21.2%, in IV group – 34.2%.

Conclusions: It was determined that the level of uric acid was increasing with age and the highest level of some components of metabolic syndrome (triglyceride, cholesterol, systolic and diastolic pressure) was among women and men with hyperuricemia. The higher level of uric acid was found among women in postmenopausal period with maximal body mass index (BMI>35).

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.