Endocrine Abstracts

Fat tissue is highly active tissue, both metabolically and as endocrine tissue, which produced large number of bioactive peptides, known as adipocitokines. They seem to contribute in pathogenesis of obesity, insulin resistance, diabetes mellitus type 2, hypertension, hyperlipidemia, and vascular disease. Adipocitokines and low grade inflammation could be connection between obesity and coexisting diseases. This is the reason we believe that body weight reduction could have positive effects on decreasing the risk for those diseases. The aim of this study is to evaluate the effect of hypo caloric diet and body weight reduction on serum levels of leptin, adiponectin and inflammatory markers in obese woman and their correlations. Methodology and material: We included in the study 90 obese women, with body mass index (BMI) 36.43±5.42; waist circuference (WC) 103.12±14.33; weist circuference/hip circuference ratio (WC/HC) 0.89 ±0.08. In all subjects we determined serum levels of leptin,adiponectin, CRP and fibrinogen before and after six months of hypo caloric diet and body weight reduction. Results: Average weight loss was 8.73±1.98 kg or 8.64±1.96% (P<0.001). That results in significant decreasing of anthropometric parameters, BMI, WC and WC/HC ratio, (P<0.001). Serum levels of leptin, CRP and fibrinogen decreased and serum level of adiponectin increased, all on maximum level of statistical significance (P<0.001). There is statistically significant positive correlation between anthropometric parameters and inflammatory markers, before and after body weight reduction. There is positive correlation between leptin, and negative correlation between adiponectin and anthropometric parameters. Before and after body weight reduction there is statistically positive correlation between leptin and negative correlation between adiponectin and serum levels of CRP and fibrinogen. Conclusion: Our results suggests that changes in adipocitokines and state of low grade inflammations are connected and that body weight reduction has significant positive effect on all parameters, what emphasizes the importance of restricted dietary regime as therapy of obesity.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.