Obestatin does not modify weight and nutritional behavior but is associated to metabolic syndrome in old women

M. Mora; M. Granada; R. Puig; M. Roca; E. Palomera; I. Olaizola; M. Julian; M. Serra-Prat; M. Puig-Domingo

P1137

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Endocrine Abstracts (2012) 29 P1137

ICEECE2012 Poster Presentations Neuroendocrinology (83 abstracts)

Obestatin does not modify weight and nutritional behavior but is associated to metabolic syndrome in old women

M. Mora ¹ , M. Granada ² , R. Puig ² , M. Roca ³ , E. Palomera ³ , I. Olaizola ² , M. Julián ² , M. Serra-Prat ³ & M. Puig-Domingo ²

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¹Hospital Clínic of Barcelona, Barcelona, Spain; ²Hospital Germans Trias i Pujol, Badalona, Spain; ³Hospital of Mataró, Mataró, Spain.

Introduction: Ghrelin gene products ghrelin and obestatin have apparent opposite orexigenic and anorexigenic effects, although this latter has not been firmly demonstrated for obestatin in humans. So far, no information has been reported in relation to its potential association to metabolic syndrome (MS).

Objective: To study obestatin concentrations in relation to nutritional parameters and eating behavior in old women.

Methods: One hundred and ten women (age 76.93±6.32) from the Mataró Ageing Study were included. Individuals were phenotypically characterized by anthropometric variables, lipids, glucose, blood pressure, MS components (ATP-III criteria), anorexia assessed by a questionnaire and nutritional status by MNA-SF. A further reevaluation was performed at 2-years follow-up. Obestatin was measured by an IRMA.

Results: 58.2% of the subjects had metabolic syndrome; at 2-y follow-up 24.1% had a weight loss>5% and 7.2%>10%, and 26.4% changed their MNA score to risk of malnutrition category. Anorexia was present in 38.4%. Obestatin levels were not related to either change of weight, MNA and anorexia, but a positive correlation was found with waist circumference (WC) (P=0.039, rs=0.200), to the absolute Δ between basal vs 2-y WC (Ps<0.001; rs=0.459), relative Δ between basal vs 2-y WC (Ps<0.001; rs=0.447); both absolute and relative WC Δ remained significant after adjusting for age and BMI. When obestatin was divided in quartiles, a significant lineal trend was observed in relation to WC (P=0.049), absolute and relative Δ between basal vs 2-y WC (both P<0.01). Glucose impairment was associated to obestatin (69.0% in 4th quartile had glucose impairment vs 44.4% in 1st; P=0.021) and to MS by ATP-III (77.8% had MS in 4th quartile, 36% in 3rd, 60% in 2nd vs 57.7% in 1st; P=0.025).

Conclusions: Obestatin is elevated in aged women bearing MS but is otherwise not associated to other nutritional parameters, weight loss or anorexia.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This work was supported, however funding details unavailable.