Total Testosterone levels and predisposing criteria for metabolic syndrome in healthy young men

A. Hlazkova; N. Murashko; L. Danilova; A. Romanouski; N. Yaroshevich; D. Raduk; E. Dashkevich; V. Pishchik

Object of the study: To evaluate total testosterone (TT) levels in healthy young men and determine its possible influence on metabolic syndrome risk factors.

Materials and methods: One hundred and twenty-six practically healthy young men, mean age 20.16±1.42 years old (18–29) were included in the study. Individuals with any clinical manifestations suspicious for hypogonadism, chronic liver and kidney diseases in the anamnesis or receiving any kind of long-term medical therapy were excluded from the study. Evaluation of every patient consisted of general examination, anthropometric data, blood pressure, blood samples for serum glucose, lipid spectrum, total testosterone and LH.

Results please see Table 1.: During the correlation analyses of total testosterone and its dependence of following indicators of metabolic syndrome: BMI, WC, systolic and diastolic blood pressure, TG and HDLP, positive correlation with serum HDLP level (r=0.2016, P <0.05) has been established. Despite the fact that, obesity and overweight indicators - BMI and WC are not connected with the level of total testosterone in healthy young men, we managed to establish significant correlation between total testosterone level and % of VF (r=0.2014, P<0.05)

Conclusion: In young men without metabolic syndrome manifestation has been established significant correlation between total testosterone level and % of visceral fat and HDLP level.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

**Table 1**
Parameters	Mean	M± S.D.
BMI, body mass index	22.77	20.427; 25.116	kg/m²
WC, waist circumference	75.5	70.0687; 80.9967	Cm
TF, total fat	22.11	16.8495; 27.3595	%
VF, visceral fat	5.03	2.5481; 8.7181	%
SBP, systolic blood pressure	119.9	108.85; 131.163	MmHg
DBP, diastolic blood pressure	75.53	66.328; 80.7461	mmHg
TT (IFA), total testosterone	6.78	5.0424; 8.527	nmol/l
LH (IFA), luteinize hormone	5.05	3.0839; 4.0837	nmol/l
TC, total cholesterol	3.56	3.0388; 4.0837	mmol/l
TG, triglyceride	0.889	0.4753; 1.3027	mmol/l
HDLP, high density lipoprotein	1.18	0.925; 1.4332	mmol/l
LDLP, low density lipoprotein	1.937	1.4608; 2.4147	mmol/l

Endocrine Abstracts

P1012