Endocrine Abstracts

IGF1 represent an important key player in several physiologic process, so it can be implicated in different pathologies among delays of growth. A comparative study was realized comparing a group of healthy Algerian children of normal size (n: 266) and a group presenting a GH deficiency (GHD n: 107)to a group of healthy westerners children of normal size(Serie of ROSENFIELD).

The results are as follows: Before the age of 04 years, there is a great overlapping in the results of IGF1 between children who suffer from GHD and those of the comparative group.

After this age, results of IGF1 are significantly low in GHD subjects, compared to the Algerian reference group.

The values of IGF1 found in the Algerian healthy subjects are significantly lower than those observed in the western healthy children. So this parameter must be carefully interpreted when investigating a delay of growth in Algerian and must take into account the clinical and biological context of the patient. It is necessary to establish Algerian standards for IGF1. The introduction of the IGFBP3 not yet available would be more interesting in our context.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.