ICEECE2012 Poster Presentations Obesity (114 abstracts)
Leptin modulates brain neural activity associated with feeding behavior in patients with lipodystrophy
D. Aotani , K. Ebihara , N. Sawamoto , T. Kusakabe , M. Aizawa-Abe , S. Kataoka , T. Sakai , C. Ebihara , J. Fujikura , K. Hosoda , H. Fukuyama & K. Nakao
Kyoto university, Kyoto, Japan.
Introduction: Markedly decreased plasma leptin concentrations in patients with lipodystrophy commonly lead to overeating. Leptin-replacement therapy improves feeding behavior in these patients. The aim of the present study is to clarify neural networks influenced by leptin signals for appetite regulation in the patients with lipodystrophy.
Methods: We measured neural responses to visual food stimuli by use of functional magnetic resonance imaging (fMRI) and investigated subjective feeling on appetite under both fasting and postprandial conditions in ten patients with or without leptin-replacement therapy and age- and sex-matched ten healthy subjects.
Results: In fMRI analysis, significant difference of food-related neural activity between controls and patients was detected in many regions under postprandial condition, while only in a few area under fasting condition. Leptin increased neural activity in a region involved in satiety and suppressed in regions involved in hunger in patients under postprandial condition, while altered only in a few areas under fasting condition. In subjective feeling, there was no apparent difference of hunger feeling under fasting condition, while postprandial satiety feeling in patients was significantly reduced compared to controls, which was effectively increased by leptin.
Conclusion: These findings may suggest that improvement of feeding behavior by leptin is associated with modulation of neural processing in the brain regions involved in energy homeostasis and appetite regulation.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more