Young Active Researchers Symposium (YAR)

ea0029s70.1 | Young Active Researchers Symposium (YAR) | ICEECE2012

New mechanisms underlying the role of the mTORC1 pathway in the hypothalamic control of energy balance

Similar to individual cells, hypothalamic neural circuits profit from intracellular pathways known to work as fuel sensors to maintain energy balance.The mammalian target of rapamycin complex 1 (mTORC1) signaling cascade is among the latest intracellular fuel-sensing pathways to be implicated in the hypothalamic regulation of energy balance.mTORC1 activity is found in both NPY/AgRP- and POMC-producing neurons of the arcuate nucleus...

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ea0029s70.2 | Young Active Researchers Symposium (YAR) | ICEECE2012

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ea0029s70.3 | Young Active Researchers Symposium (YAR) | ICEECE2012

DNA methylation of the body weight-regulating proopiomelanocortin gene: functional and ontogenetic aspects

Mischke M. , Kuehnen P. , Grueters A. , Krude H.

Obesity is a polymorphic chronic disease with epidemic prevalence. Furthermore, heritability of the weight phenotype is high. However, within the catabolic leptinmelanocortin signalling pathway, which is pivotal for body weight regulation, gene mutations are rare. This indicates that other, non-genetic heritable factors might play a role in the development of obesity, such as epigenetic mechanisms.In a candidate gene approach, we analyzed the funct...

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ea0029s70.4 | Young Active Researchers Symposium (YAR) | ICEECE2012

Mineralocorticoid receptor antagonism counters metabolic dysfunctions induced by high fat diet in mice

Cinti F. , Young M. , Cranston G. , Fletcher E. , Marzolla V. , Armani A. , Antelmi A. , Fabbri A. , Caprio M.

Drospirenone (DRSP) is a potent antimineralocorticoid with progestative and moderate antiandrogenic properties. We have previously shown that DRSP exerts a potent antiadipogenic activity in murine and human preadipocytes through specific antagonism of the MR. In the present study responses to DRSP were investigated in a model of diet-induced obesity for 12 weeks. Female 10-week-old C57bl6 mice were fed with normal chow or a high fat diet (HF, containing 45% fat by calories). M...

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ea0029s70.5 | Young Active Researchers Symposium (YAR) | ICEECE2012

A four-week fat overfeeding study in constitutional thin women: a human model of weight gain resistance

Germain N , Galusca B , Feasson L , Grouselle D , Epelbaum J , Minnion J , Laville M , Vidal H , Boirie Y , Estour B

Introduction: Constitutional thinness (CT) is a rare condition of natural low body weight, with normal menstruation, no fear of weight gain and no hormonal abnormalities except for an anorexigenic hormonal profile. CT can be considered as the opposite of obesity and its resistance to weight loss. Therefore, we hypothesised they would have a resistance to weight gain.Methods: 10 female Controls (BMI 18.525 kg/m2) and 10 CT women (BMI<...

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Endocrine Abstracts

15th International & 14th European Congress of Endocrinology

Symposia

New mechanisms underlying the role of the mTORC1 pathway in the hypothalamic control of energy balance

DNA methylation of the body weight-regulating proopiomelanocortin gene: functional and ontogenetic aspects

Mineralocorticoid receptor antagonism counters metabolic dysfunctions induced by high fat diet in mice

A four-week fat overfeeding study in constitutional thin women: a human model of weight gain resistance

BiosciAbstracts