Endocrine Abstracts

SCS is defined as an adrenal tumor (usually adenoma) with autonomous cortisol secretion and no overt symptoms of Cushing’s syndrome. SCS has attracted much attention because it often is masked by lifestyle-related diseases such as diabetes mellitus (DM), metabolic syndrome (MS) and hypertension. Because of the broad variation in autonomous cortisol secretion among patients, diagnostic criteria for SCS have not been fully established. Furthermore, the cut-off values of the...

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Autoimmune Addison’s disease (AAD) occurs in approximately 1:8000 individuals. Its autoimmune pathogenesis is made evident by the presence of circulating 21-hydroxylase autoantibodies. A recent international program aimed at standardizing adrenal autoantibody measure to optimize both the etiological classification of the disease and the identification of at-risk subjects. Approximately 1% of subjects with autoimmune endocrine diseases and 5% of women with primary ovarian ...