Endocrine Abstracts

The ‘coupling’ concept of bone resorption and formation was developed at both the whole-body and microscopic levels in the 1960’s. At the whole-body level, ‘coupling’ served to explain a positive correlation observed between whole body rates of bone resorption and formation, as determined by radiocalcium kinetics. At the microscopic level, ‘coupling’ describes sequential bone remodeling at each basic multicellular unit (BMU), in which bone re...

In addition to cellular interactions via cytokines, the immune and skeletal systems share various molecules, including transcription factors, signaling molecules and membrane receptors1. RANKL stimulates osteoclastogenesis through NFATc1 in cooperation with immunoglobulin-like receptors, using the immunomodulatory molecules for signalling2. Here I will discuss emerging topics in osteoimmunology including the mechanisms underlying bone cell communication: ...

Coupling of bone formation subsequent to bone resorption is a fundamental mechanism for sustaining bone density in adults. We have demonstrated that TGFβ1 released from the bone matrix during osteoclastic bone resorption induces the migration of bone marrow mesenchymal stem cells (MSCs). We also found that IGF1 released from bone matrix responsible osteoblast differentiation of MSCs recruited by TGFβ1 during bone remodeling. TGFβ1 released from the bone matrix d...