Endocrine Abstracts

While it is well known that hyperthyroidism leads to weight loss, and hypothyroidism is associated with weight gain, there has been an increasing focus on the relationship between thyroid function and body weight in recent years. A moderate elevation of TSH concentrations, which is associated with triiodothyronine (T3) values in or slightly above the upper normal range, is frequently found in obese humans. These thyroid hormone alterations in obesity seem rather a c...

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One of the major routes for metabolism of thyroid hormones is by deiodination through the iodothyronine deiodinases, an enzyme family consisting of three members, types 1 (D1), 2 (D2) and type 3 (D3). The outer ring of thyroxin (T4) can be deiodinated by D2, leading to the formation of active hormone, triiodothyronine (T3). D2 is expressed predominantly in the brain and pituitary, but also in brown adipose tissue and muscle. Within the cell, D2 is localiz...