Endocrine Abstracts

For patients with Graves’ disease (GD), the primary goal of antithyroid drug therapy is to temporarily restore the patient to the euthyroid state and wait for a subsequent remission of the disease. This study sought to identify the predictive markers for the relapse of disease.To do this, we studied 262 GD patients with long enough follow-up after drug withdrawal to determine treatment outcome. The patients were divided into three groups by time of ...

Graves’ disease (GD) is a heterogeneous disorder affecting with varying degrees of severity the thyroid and eyes. This variety may suggest that complex interactions between genetic, environmental and endogenous factors influence the clinical course of GD. Although the genetic predisposition to GD is well established, the significance of genotype-phenotype correlations remains controversial. Moreover, the lack of complete phenotypic concordance in twin studies suggested th...

Human autoimmune thyroid diseases (AITD), mainly including Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), are characterized by reactivity to self-thyroid antigens. Regulatory T cells have an important role in immune tolerance to self-antigens. We have reported that different regulatory T cell subsets are abundant in the peripheral blood and in inflamed thyroid tissue in AITD and are able to synthesize the immunoregulatory cytokines IL-10 and TGF-beta. However...