Endocrine Abstracts

TH are derived from the iodinated amino acid tyrosine and coupled to their typical diphenylether structure. Metabolic modifications of TH lead to activation, inactivation or novel quality not exerted by the parent molecule L-T4. Phenolic-5′-(outer) and tyrosyl-3′-(inner ring) deiodination are well known metabolic pathways. Activating 5′deiodination of T4 to T3 is catalysed by two distinct DIO1 and DIO2 selenoproteins, with dis...

Thyroid hormones T4 and T3 regulate many different physiological processes in different tissues in vertebrates. Most of the actions of thyroid hormones are mediated by the thyroid hormone receptor (TR), which is a member of the nuclear receptor superfamily of ligand-activated transcription regulators. There are two different genes that encode two different TRs, TR alpha and TR beta, and these two TRs are often co-expressed at different levels in different...

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