Endocrine Abstracts

Circadian clocks regulate the adaptation of the organism to the rotation of the earth around its axis. In mammals the circadian timing system is comprised of numerous cellular oscillators throughout the brain and the body. In the hypothalamic suprachiasmatic nucleus a circadian pacemaker is synchronized to the external light/dark cycle via direct innervation along the retinohypothalamic tract. From the SCN, peripheral clocks are synchronized by neuronal, endocrine and behavior...

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Circadian mechanisms regulate metabolism in adipose tissues. The genes encoding the circadian regulatory proteins oscillate over a 24 h period in human and murine adipose tissue depots,. This expression profile is entrained by photic stimuli, temporally restricted food access, and/or nuclear hormone receptor ligands, such as glucocorticoids. In mice, deletion or mutation of the circadian regulatory genes, clock and PPAR gamma coactivator 1 (PGC1), is associated with increased ...