Endocrine Abstracts

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There is an increased prevalence of metabolic syndrome in patients with severe GH deficiency. Prior studies used different criteria to define metabolic syndrome but in spite of this limitation, several studies indicate that GH therapy improves many of these parameters. The variable that shows the greatest improvement is waist circumference. Some studies show improvement in both systolic and diastolic blood pressure and in HDL cholesterol. Definitive evidence of decreased level...

A wealth of evidence has substantiated GLP-1’s role in regulating appetite and energy intake in humans. Meta-analyses confirm that i.v. infusion of native GLP-1 reduces energy intake in lean and overweight subjects1. A high-protein diet is known to increase satiety and this effect appears to be at least partly mediated by GLP-1. Increased post-prandial GLP-1 levels have been measured in healthy subjects following high-protein meals compared with medium- and low...