Endocrine Abstracts

The most important cause of death as men age is cardiovascular disease and as men age so their androgen status declines. Studies have shown that lowering of endogenous androgen by deprivation therapy as treatment for prostate cancer increases the risk of cardiovascular death. In long term studies, low blood testosterone is associated with accelerated atherosclerosis as manifest in coronary, aortic and carotid vascular territories.Animal models of hypogon...

Abstract unavailable....

For >50 years female cardioprotection was attributed to premenopausal endogenous estrogen levels. We describe here how cardioprotection is greatly reduced in the presence of diabetes and endogenous testosterone levels.Forty years ago we measured total and bioavailable testosterone (bioT), total and bioavailable estradiol, and SHBG in community-dwelling older men and women from the Rancho Bernardo Study, using organic solvent extraction and celite col...