ea0029eje1 | The European Journal of Endocrinology Prize Lecture | ICEECE2012
Farooqi S
Whilst the rise in the prevalence of obesity has been driven by environmental factors, there is considerable evidence that body weight and fat mass are highly heritable traits. Differences in susceptibility to obesity between individuals have strong genetic determinants.Our strategy has been based on studies of patients with severe obesity where we hypothesised that major highly penetrant genetic variants were likely to be playing an important role.<...