Hypothyroxinemia and pregnancy

M. Amani; F. Chentli; S. Amani; N. Midoun; N. Benfeghoul; A. Rih; L. Zemour; N. Boumansour

Introduction: The maternal hypothyroxinemia would be an adaptive process of the thyroid gland to iodine deficiency, regardless of the TSH. Our objectives are the prevalence and pathophysiological approach of hypothyroxinemia in pregnant women in the 1st quarter.

Description of methods: Labor-looking statements, made in Oran area, on 270 pregnant women in 1st quarter. Women who smoke (active smoking confessed) and those followed for thyroid disease or taking medications that interfere with the thyroid gland were excluded.

Study protocol: clinical examination, TSH, FT4, FT3, anti-TPO, anti-thyroglobulin, TSI and urinary iodine. Statistics tests: collection of data on EPI INFO 5.1, bivariate analysis (the chi-squared test, the Pearson chi-squared test, the Yates corrected chi-squared test, the Wilcoxon chi-squared test (Log rank sum) or Mann-Whitney, the variance analysis method (ANOVA), the r correlation test, significance level P<0.05, multivariate analysis (SPSS: 10 version and MedCalc).

Results: -22/270 pregnant women in 1st quarter (8.1%) had a hypothyroxinemia which 21/22 had benefited from a determination of iodide.

−06/21 cases (28.6%) had an inadequate iodine intake (urinary iodine <150 μg/l).

-09/21 cases (42.9%) had correct urinary iodine (between 150 and 250 μg/l).

−06/21 cases (28.6%) had a more than adequate iodine intake (urinary iodine ≥250 μg/l).

Conclusion: Although the pathophysiological mechanisms of hypothyroxinemia during pregnancy are not yet well understood, the knowledge of the disease is nevertheless appropriate given its harmful consequences.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector

Endocrine Abstracts

P1748