Endocrine Abstracts

Materials and methods: The study included 58 patients (50 female, 8 males) aged from 38 to 60 years, have received surgical treatment for GD with the period of follow-up after treatment for 2 to 10 years. The patients were divided into 2 groups depending on the initial level of TSH. In the first group (33 persons) included patients with low-normal level of TSH (0.4–2.5 mU/ml), the in second group (25 persons) with upper-normal level of TSH (2.6–4.0 mU/ml). An estimation of the psychoemotional status was conducted by means of a scale of depression of Beck and Spielberg-Khanins test.

Results: The groups were comparable for gender, duration after treatment, dose of L-T4. In the first group the median age of patients was 43 years (35;50), the amount of points depression was 10 (2;19), which corresponds to easy depression, the median amount of points situational anxiety 39 (23;50), personal alarm 40 (23;59), which corresponds to a moderate level of anxiety.

In the second group the median age was 56 years (49;64), the amount of points depression was 16 (2;29), which corresponds to mild depression, the median amount of points situational anxiety 44 (25;60), personal alarm 44 (31;67), which corresponds to a moderate level of anxiety.

In the evaluation of mean values of the psychoemotional status in the first and second group, statistically significant differences were observed on all scales (P<0.05).

Conclusions: there are significant differences of the psychoemotional status (presence of anxiety and depression) among patients with upper- and low-normal TSH. It is established that patients with upper-normal TSH had the worst performance, in the course of our study revealed a statistically significant difference between all scales, but most likely due to age.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector