ICEECE2012 Poster Presentations Thyroid (non-cancer) (188 abstracts)
Serum nesfatin-1 levels in overt and subclinical hyperthyroidism
A. Güngünes 1 , Z. Ginis 1 , T. Demirci 1 , E. Cakir 1 , B. Karbek 1 , M. Sayki Arslan 1 , I. Ozturk Unsal 1 , E. Tutal Akkaya 1 , B. Ucan 1 , E. Cakal 1 , S. Gultuna Ozguclu 2 , M. Ozbek 1 , M. Sahin 2 , O. Topaloglu 1 & T. Delibasi 1
1Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey; 2School of Medicine, Ankara University, Ankara, Turkey.
Objective: Nesfatin-1, was recently discovered in the brain which is derived from nucleobindin2 (NUCB2). Central and peripheral administration of nesfatin-1, inhibits food intake, dose-dependently. Hyperthyroid patients have increased appetite and food intake with a craving for carbohydrate-rich food, at the beginning of disease, but the physiological mechanisms underlying this behavior is not known exactly. In this study, we investigated whether nesfatin-1 is involved in the regulation of appetite and body weight in hyperthyroidism, or not.
Methods: A total of 70 patients with subclinical and overt hyperthyroidism compared with 35 control patients. Serum nesfatin-1 level was measured from all samples by commercial ELISA kit.
Results: Serum free T3 and free T4 levels in the overt hyperthyroidism group was significantly higher and serum TSH level in the overt hyperthyroidism group was significantly lower than subclinical hyperthyroid and control group respectively (P<0.001). In addition, the TSH levels in the subclinical hyperthyroid group was significantly lower than control group (P<0.001). Serum nesfatin-1 levels were similar between three groups (P=0.293). After adjusting for age and body mass index, nesfatin-1 levels in control group was not different from subclinical and overt hyperthyroid group respectively (P=0.567 and P=0.519). However, there was a significant correlation between nesfatin-1 and platelet, free T3 vs TSH receptor antibody levels (P<0.05).
Conclusion: These data showed that serum nesfatin-1 levels do not significant change in overt and subclinical hyperthyroidism.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
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Endocrine Abstracts
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