Evaluation of the effect of radioactive iodine treatment on urea breath test

A. Arduc; U. Ozuguz; Y. Tutuncu; Dogan B. Aycicek; M. Tuna; I. Peksoy; F. Gokay; D. Berker; S. Guler

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Endocrine Abstracts (2012) 29 P1653

ICEECE2012 Poster Presentations Thyroid (non-cancer) (188 abstracts)

Evaluation of the effect of radioactive iodine treatment on urea breath test

A. Arduc ¹ , U. Ozuguz ² , Y. Tutuncu ¹ , B. Aycicek Dogan ¹ , M. Tuna ¹ , I. Peksoy ¹ , F. Gokay ¹ , D. Berker ¹ & S. Guler ¹

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¹Ministry of Health, Ankara Numune Research and Training Hospital, Ankara, Turkey; ²Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey.

Introduction: Helicobacter pylori (HP) infection is the most significant cause of gastritis and related morbidities. Radioactive iodine treatment (RAIT) is an important option in the treatment of hyperthyroidism. In addition to thyroid gland, RAI accumulates in stomach in significant amounts. In our study, we planned to investigate whether RAIT has an effect on carbon-14-urea breath test (UBT) in patients with hyperthyroidism.

Materials-method: The study included 71 patients that were planned to give RAIT due to hyperthyroidism. Patients that used antibiotics in the last month and proton pump inhibitor in the last week, pregnant women, individuals with stomach operation history were excluded from the study. The entire patients were implemented UBT an hour before RAIT for the detection of HP infection. Patients whose test came out positive were repeated UBT one month following the treatment.

Results: Of the 71 patients, 62 had positive UBT before RAIT. Of the 62 patients, 52 were female and 10 were male, and the mean age was 53.9±12. Following an average 15 mci (10–20) RAI dose, UBT became negative in 10 out of 62 patients (17.3%). The rate of negativity was found to be 17.3% in females and 10% in males; and significant difference did not occur (P=1). When the patients were divided into groups as 20 mci (group 1), 15 mci (group 2), and 10 mci (group 3) based on RAI doses, UBT negativity rates were 7 (25%), 2 (10.5%), and 1 (6.7%), respectively, and the difference was not statistically significant (P=0.206).

Conclusion: RAIT in low doses does not have an effect on UBT. However, UBT negativity rate increases parallel to the treatment dose. Further studies that investigate the relation between HP radiosensitivity and RAI dose are needed.

Keywords: Helicobacter pylori, radioactive iodine treatment, carbon-14-urea breathe test.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.