ICEECE2012 Poster Presentations Thyroid (non-cancer) (188 abstracts)
Iodine prophylaxis in pregnant women: effects on offspring and the mother’s thyroid hormones
P. Santiago 1 , I. Velasco 2 , J. Muela 3 , B. Sanchez 1 , J. Martínez 1 , C. Sánchez 1 , A. Rodriguez 3 , F. Soriguer 2 & Maria Berrio 2
1SAS/Ch Jaen, Jaen, Spain; 2SAS/ Hospital de Riotinto, Huelva, Spain; 3Universidad de Jaen, Jaen, Spain; 4SAS/Hospital Carlos Haya, Malaga, Spain.
Background and aims: Use of potassium iodide (PI) supplements during gestation in mild to moderate iodine deficiency areas remains a controversial issue.
Objective: Comparing the pharmacological effect of iodized salt versus iodide potassium supplements on the maternal thyroid function and neurodevelopment (Bayley Scales) of the progeny.
Methods: One hundred and thirty one pregnant women were included from the first trimester (below 10 weeks of amenorrhea) with random allocation in three groups: A) Iodized salt B) 200 mcg of iodide potassium (PI) per day and C) 300 mcg of PI per day.
Main outcome measures: Thyroid function parameters (TSH, FT4, FT3 and urinary iodine excretion) and Bayley-III Scales of Infant Development in children.
Results: The thyroid function tests in three trimesters of gestation and postpartum have not shown significant differences between the three treatment groups, except in urinary iodine excretion (higher in group treated with 300 mcg PI/day). In direct scores of psychometrical scales, we found higher scores within the sons whose mothers were supplied with lodizet salt at 300 mcg PI/day. We found a positive relation between motherbreed urinary iodine, mental scales and Bayley tests in every age group; However, there is not any relation between urinary iodine and psychomotor scale.
Conclusions: Actually It is necessary to maintain an accurate iodic nutrition on these women in fertile age, that is why the usage of pharmacological supplements of 200–300 mcg of PI is well recommended in iodine deficient areas.The use of pharmacological supplements of PI is safe and doesn’t alter the maternal thyroid function, even improves the urinary iodine excretion. But if you use iodized salt regularly, you may not have need for iodine supplementation in the future.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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